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- Keanu Reeves as Alex Wyler
- Sandra Bullock as Kate Forster
- Christopher Plummer as Simon J. Wyler
- Ebon Moss-Bachrach as Henry Wyler
- Shohreh Aghdashloo as Dr. Anna Klyczynski
- Dylan Walsh as Morgan Price
- Willeke van Ammelrooy as Mrs. Forster
- Lynn Collins as Mona
- Mike Bacarella as Mulhern
- Kevin M. Brennan as Waiter
- Frank Caeti as Cove Patron
- Aliyah Carr as Girl Patient
- Scott Elias as Doug