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- Forest Whitaker as Idi Amin
- James McAvoy as Nicholas Garrigan
- Kerry Washington as Kay Amin
- Gillian Anderson as Sarah Merrit
- Simon McBurney as Stone
- David Oyelowo as Dr. Junju
- Apollo Okwenje Omamo as Mackenzie
- Stephen Rwangyezi as Jonah Wasswa
- Abby Mukiibi Nkaaga as Masanga
- Adam Kotz as Dr. Merrit
- Sam Okelo as Bonny
- Sarah Nagayi as Tolu