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- Ally Sheedy as Helen Jordan
- Allison Janney as Trish Jordan
- Ciaran Hinds as Bill Maplewood
- Chris Marquette as Billy Maplewood
- Paul Reubens as Andy
- Michael Kenneth Williams as Allen Mellencamp
- Shirley Henderson as Joy Jordan Mellencamp
- Charlotte Rampling as Jacqueline
- Renee Taylor as Mona Jordan
- Michael Lerner as Harvey Wiener
- Dylan Riley Snyder as Timmy Maplewood
- Rich Pecci as Mark Wiener
- Gaby Hoffmann as Wanda