Lorenzo's Oil
Lorenzo's Oil
Directed By George Miller
Written By George Miller, Nick Enright
Cast Susan Sarandon, Nick Nolte, Peter Ustinov, James Rebhorn
Produced By Doug Mitchell, George Miller
Film Editing By Richard Francis-Bruce, Marcus D'Arcy
Cinematography By John Seale

United States



Release Date

December 30, 1992


129 Minutes

Rating PG-13
Distributed By

Universal Pictures

Budget $30,000,000
Gross $7,286,310


The film is based on a true story about Augusto and Michaela Odone who struggled to find a cure for their son, Lorenzo who suffers from ALD (adrenoleukodystrophy). It's a sex linked disease, specifically caused by a X-linked recessive trait, where the body cannot digest long fatty acids. The accumulation of these long fatty acid chains cause destruction of myelin sheathes.



  • Nick Nolte as Augusto Odone
  • Susan Sarandon as Michaela Odone
  • Peter Ustinov as Professor Nikolais
  • Kathleen Wilhoite as Deirdre Murphy
  • Gerry Bamman as Doctor Judalon
  • Margo Martindale as Wendy Gimble
  • James Rebhorn as Ellard Muscatine
  • Ann Hearn as Loretta Muscatine
  • Maduka Steady as Omouri
  • Colin Ward as Jake Gimble
  • La Tanya Richardson as Nurse Ruth
  • Jennifer Dundas as Nurse Nancy Jo
  • William Cameron as Pellerman
  • Becky Ann Baker as Pellerman's Secretary
  • Mary Pat Gleason as The Librarian
  • David Shiner as Clown
  • Ann Dowd as Pediatrician
  • Peter Mackenzie as Immunosuppression Doctor
  • Paul Lazar as Professor Duncan
  • Laura Linney as Young Teacher
  • Mary Schmidt Campbell as Principal
  • Michael O'Neill as School Psychologist
  • William Thunhurst, Jr. as Ear Specialist
  • Ann McDonough as Dietician
  • Vladimir Padunov as Russian Translator
  • David McFadden as Father Killian
  • Carmen Piccini as Cristina Odone