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- Diane Keaton as Bridget Cardigan
- Queen Latifah as Nina Brewster
- Katie Holmes as Jackie Truman
- Ted Danson as Don Cardigan
- Roger Cross as Barry
- Adam Rothenberg as Bob Truman
- Stephen Root as Glover
- J.C. MacKenzie as Mandelbrot
- Christopher McDonald as Bryce Arbogast
- Finesse Mitchell as Shaun
- Bryan Massey as Detective Brinkley