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- Denzel Washington as John W. Creasy
- Dakota Fanning as Guadalupe "Lupita" Martin Ramos
- Radha Mitchell as Lisa Martin Ramos
- Marc Anthony as Samuel Ramos
- Christopher Walken as Paul Rayburn
- Giancarlo Giannini as Miguel Manzano
- Rachel Ticotin as Mariana Garcia Guerrero
- Jesus Ochoa as Victor Fuentes
- Mickey Rourke as Jordan Kalfus
- Angelina Pelaez as Sister Anna
- Roberto Sosa as Daniel Sanchez
- Gero Camilo as Aurelio Sanchez
- Mario Zaragoza as Jorge Ramirez