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- Alfre Woodard as Eunice Evers
- Laurence Fishburne as Caleb Humphrey
- Craig Sheffer as Dr. Douglas
- Joe Morton as Dr. Sam Brodus
- Obba Babatunde as Willie Johnson
- Ossie Davis as Mr. Evers
- E.G. Marshall as The Senate Chairman
- Donzaleigh Abernathy as Nurse Betty