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- Jennifer Lopez as Charlie Cantilini Fields
- Michael Vartan as Dr. Kevin Fields
- Jane Fonda as Viola Fields
- Wanda Sykes as Ruby
- Adam Scott as Remy
- Monet Mazur as Fiona
- Annie Parisse as Morgan
- Will Arnett as Kit
- Elaine Stritch as Gertrude Fields
- Stephen Dunham as Dr. Paul Chamberlain