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- Thomas Jane as Sergeant John Mitchell "Mitch" Hunter
- Ron Perlman as Brother Samuel
- Devon Aoki as Corporal Valerie Chinois Duval
- Benno Furmann as Lieutenant Maximillian Emile von Steiner
- Sean Pertwee as Nathan Rooker
- John Malkovich as Constantine
- Anna Walton as Severian
- Luis Echegaray as Corporal Jesus "El Jesus" de Barrera
- Shauna Macdonald as Adelaide
- Tom Wu as Corporal Juba Kim Wu
- Steve Toussaint as Captain John Patrick McGuire
- Roger Ashton-Griffiths as Science Monk
- Curtis Walker as Bigboy