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- Albert Brooks as Randall 'R' Harris
- Leelee Sobieski as Jennifer "J" Wilson
- John Goodman as Benjamin Wilson
- Carol Kane as Mrs. Benson
- Michael McKean as Bob Benson
- Henry Brown as Jack Taylor
- Desmond Harrington as Randy Harris, Jr.
- Mary Kay Place as Nurse Patty
- Gary Bullock as Mr. Smithman
- Nic Costa as Blaine
- Pauley Perrette as Bebe