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- Jeremy Renner as Ned
- Gabrielle Union as Rachael
- Sally Kirkland as Shelly Nelson
- Cary Elwes as Dr. Magnuson
- Eddie Kaye Thomas as Joey
- Ethan Suplee as Orderly Johnny
- Giuseppe Andrews as Josh
- Steve Railsback as Mr Day
- Richard Riehle as Officer Roy Pendleton
- Michael Shamus Wiles as Ned's Dad