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- Julia Roberts as Anna Scott
- Hugh Grant as William "Will" Thacker
- Emma Chambers as Honey Thacker
- Hugh Bonneville as Bernie
- Rhys Ifans as Spike
- Tim McInnerny as Max
- Gina McKee as Bella
- James Dreyfus as Martin
- Richard McCabe as Tony
- Dylan Moran as Rufus
- Alec Baldwin as Jeff King
- Mischa Barton as 12-Year-Old Actress