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- Renee Zellweger as Betty Sizemore
- Morgan Freeman as Charlie
- Chris Rock as Wesley
- Greg Kinnear as George McCord
- Aaron Eckhart as Del Sizemore
- Pruitt Taylor Vince as Sheriff Eldon Ballard
- Tia Texada as Rosa Hernandez
- Allison Janney as Lyla Branch
- Harriet Sansom Harris as Ellen
- Crispin Glover as Roy Ostery
- Elizabeth Mitchell as Chloe Jensen
- Kathleen Wilhoite as Sue Ann Rogers
- Sheila Kelley as Joyce