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- Parker Posey as Priscilla Chase
- Paul Rudd as Jack Chase
- Danny DeVito as Wayne Sianidis
- Mischa Barton as Kristen Taylor
- Miranda Bailey as Sherri
- Keith David as Coach Popovich
- Liza Minnelli as Alyssa Donahue
- Heather Graham as Justine
- Tim Russ as Douglas
- Adam Nelson as Kid at Vending Machine