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- Denzel Washington as Matthias Lee Whitlock
- Eva Mendes as Alex Diaz-Whitlock
- Sanaa Lathan as Anne Merai Harrison
- Dean Cain as Chris Harrison
- John Billingsley as Chae
- Robert Baker as Tony Dalton
- Alex Carter as Paul Cabot
- Antoni Corone as Deputy Baste
- Terry Loughlin as Agent Stark
- Nora Dunn as Dr. Donovan
- James Murtaugh as Dr. Frieland
- O.L. Duke as Detective Bronze