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- Steve Martin as Neal Page
- John Candy as Del Griffith
- Laila Robins as Susan Page
- Michael McKean as State trooper
- Kevin Bacon as Taxi Racer
- Dylan Baker as Owen
- Olivia Burnette as Marti Page
- Larry Hankin as Doobie
- Richard Herd as Walt
- Matthew Lawrence as Neal Page, Jr.
- Edie McClurg as St. Louis Car Rental Agent