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- Jessica Biel as Rose-Johnny
- Forest Whitaker as Charlie
- Patrick Swayze as Velvet Larry
- Ray Liotta as Jack Doheny
- Lisa Kudrow as Sally
- Riki Lindhome as Nicole
- Sanaa Lathan as Diana
- Eddie Redmayne as Qwerty Doolittle
- Kris Kristofferson as Randall
- Alejandro Romero as Lexus
- Chandler Canterbury as Billy
- Jeffery A. Baker as Slim