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- Garrison Keillor as himself
- Meryl Streep as Yolanda Johnson
- Lily Tomlin as Rhonda Johnson
- Lindsay Lohan as Lola Johnson
- Woody Harrelson as Dusty
- John C. Reilly as Lefty
- Tommy Lee Jones as The Axeman
- Kevin Kline as Guy Noir
- Virginia Madsen as Asphodel
- L.Q. Jones as Chuck Akers
- Tim Russell as The Stage Manager
- Maya Rudolph as The Assistant Stage Manager