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- Molly Ringwald as Andie Walsh
- Harry Dean Stanton as Jack Walsh
- Jon Cryer as Philip F. "Duckie" Dale
- Annie Potts as Iona
- James Spader as Steff McKee
- Andrew McCarthy as Blane McDonough
- Kate Vernon as Benny Hanson
- Andrew Dice Clay as Bouncer at CATS
- Kristy Swanson as Duckette
- Alexa Kenin as Jenna
- Dweezil Zappa as Simon
- Gina Gershon as Trombley