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- Ryan Reynolds as Andrew Paxton
- Sandra Bullock as Margaret Tate
- Mary Steenburgen as Grace Paxton
- Craig T. Nelson as Joe Paxton
- Betty White as Grandma Annie "Gammy"
- Denis O'Hare as Mr. Gilbertson
- Oscar Nunez as Ramone
- Malin Akerman as Gertrude
- Michael Nouri as Bergen
- Aasif Mandvi as Bob Spaulding
- Michael Mosley as Chuck
- Dale Place as Jim McKittrick
- Alexis Garcia as Immigration Clerk
- Alicia Hunt as Coffee Barista
- Jerrell Lee as Jordan
- Anne Fletcher as Jill