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- Dwayne Johnson as Jack Bruno
- AnnaSophia Robb as Sara
- Alexander Ludwig as Seth
- Ciaran Hinds as Henry Burke
- Carla Gugino as Dr. Alex Friedman
- Garry Marshall as Harlan
- Cheech Marin as Eddie Cortez
- Chris Marquette as Pope
- Kim Richards as Tina
- Ike Eisenmann as Sheriff Anthony
- Meredith Salenger as Natalie Gann
- Tom Woodruff Jr. as Siphon