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- Dustin Hoffman as Raymond Babbitt
- Tom Cruise as Charlie Babbitt
- Valeria Golino as Susanna
- Gerald R. Molen as Dr. Bruner
- Jack Murdock as John Mooney
- Michael D. Roberts as Vern
- Ralph Seymour as Lenny
- Lucinda Jenney as Iris
- Bonnie Hunt as Sally Dibbs
- Kim Robillard as Small Town Doctor
- Beth Grant as Mother at Farm House