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- Nicolas Cage as Herbert "H.I." McDunnough
- Holly Hunter as Edwina "Ed" McDunnough
- Trey Wilson as Nathan Arizona Sr.
- John Goodman as Gale Snoats
- William Forsythe as Evelle Snoats
- Sam McMurray as Glen
- Frances McDormand as Dot
- Randall "Tex" Cobb as Leonard Smalls
- T.J. Kuhn as Nathan Jr.
- Lynne Dumin Kitei as Florence Arizona
- Charles 'Lew' Smith as Whitey
- M. Emmet Walsh as Machine Shop Ear-Bender