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- Jeffrey Combs as Herbert West
- Bruce Abbott as Dan Cain
- Barbara Crampton as Megan Halsey
- David Gale as Dr. Carl Hill
- Robert Sampson as Dean Alan Halsey
- Al Berry as Dr. Hans Gruber
- Carolyn Purdy-Gordon as Dr. Harrod
- Ian Patrick Williams as Swiss Professor
- Gerry Black as Mace
- Peter Kent as Melvin the Re-Animated