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- Drew Barrymore as Beverly Ann "Bev" Donofrio
- Steve Zahn as Raymond "Ray" Hasek
- Brittany Murphy as Fay Forrester
- Adam Garcia as Jason Hasek
- Lorraine Bracco as Mrs. Teresa Donofrio
- James Woods as Mr. Leonard Donofrio
- Maggie Gyllenhaal as Amelia
- Mika Boorem as Bev Donofrio (age 11)
- Logan Lerman as Jason Hasek (age 8)
- Rosie Perez as Shirley Perro
- Desmond Harrington as Bobby
- Sara Gilbert as Tina Barr
- Peter Facinelli as Tommy Butcher