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- Robert De Niro as Detective Tom "Turk" Cowan
- Al Pacino as Detective David "Rooster" Fisk
- John Leguizamo as Detective Simon Perez
- Donnie Wahlberg as Detective Theodore Riley
- 50 Cent as Marcus "Spider" Smith
- Carla Gugino as Detective Karen Corelli
- Brian Dennehy as Lieutenant Hingis
- Frank John Hughes as Charles Randall
- Trilby Glover as Jessica
- Oleg Taktarov as Yevgeny Mugalat
- Rob Dyrdek as Robert "Rambo" Brady
- Papoose as Himself