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- Anthony Hopkins as Dr. John Harvey Kellogg
- Matthew Broderick as William Lightbody
- Bridget Fonda as Eleanor Lightbody
- John Cusack as Charles Ossining
- Dana Carvey as George Kellogg
- Michael Lerner as Goodloe Bender
- Colm Meaney as Dr. Lionel Badger
- John Neville as Endymion Hart-Jones
- Lara Flynn Boyle as Ida Muntz
- Traci Lind as Nurse Graves
- Camryn Manheim as Virginia Cranehill
- Roy Brocksmith as Poultney Dab
- Norbert Weisser as Dr. Spitzvogel