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- Annette Bening as Deirdre Burroughs
- Brian Cox as Dr. Finch
- Joseph Fiennes as Neil Bookman
- Evan Rachel Wood as Natalie Finch
- Alec Baldwin as Norman Burroughs
- Jill Clayburgh as Agnes Finch
- Joseph Cross as Augusten Burroughs
- Gwyneth Paltrow as Hope Finch
- Gabrielle Union as Dorothy
- Patrick Wilson as Michael Shephard
- Kristin Chenoweth as Fern Stewart
- Dagmara Dominczyk as Suzanne
- Colleen Camp as Joan
- Leslie Grossman as Sue