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- Danny DeVito as Sam Stone
- Bette Midler as Barbara Stone
- Judge Reinhold as Ken Kessler
- Helen Slater as Sandy Kessler
- Anita Morris as Carol Dodsworth
- Bill Pullman as Earl Mott
- Art Evans as Lt. Bender
- Clarence Felder as Lt. Walters
- J.E. Freeman as Bedroom Killer
- Gary Riley as Heavy Metal Kid
- Phyllis Applegate as Loan Officer
- Jeannine Bisignano as Hooker in Car