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- Pierce Brosnan as Dan Day
- Greg Kinnear as Carl Vandermeer
- Jennifer Connelly as Gwen Vandermeer
- Marisa Tomei as Honey Foster
- Ed Harris as Dr. Paul Blaylock
- Isabelle Fuhrman as Angie Vandermeer
- Jim Gaffigan as Jerry Hobson
- Ciaran Hinds as Jim Hunt
- Yul Vazquez as Jorge Guzman De Vaca