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- Jennifer Lopez as Selena
- Edward James Olmos as Abraham Quintanilla, Jr.
- Constance Marie as Marcella Quintanilla
- Jon Seda as Chris Perez
- Lupe Ontiveros as Yolanda Saldivar
- Jackie Guerra as Suzette Quintanilla
- Jacob Vargas as A.B. Quintanilla
- Alexandra Meneses as Sara
- Rebecca Le Meza as Young Selena
- Panchito Gomez as Young Abraham
- Victoria Elena Flores as Young Suzette
- Rafael Tamayo as Young A.B.
- Ruben Gonzalez as Joe Ojeda
- Seidy Lopez as Deborah