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- Bradley Cooper as Patrick "Pat" Solatano, Jr.
- Jennifer Lawrence as Tiffany Maxwell
- Robert De Niro as Patrizio "Pat" Solatano, Sr.
- Jacki Weaver as Dolores Solatano
- Anupam Kher as Dr. Cliff Patel
- Chris Tucker as Danny McDaniels
- Julia Stiles as Veronica
- Brea Bee as Nikki Solatano
- Shea Whigham as Jake Solatano
- John Ortiz as Ronnie
- Paul Herman as Randy
- Dash Mihok as Officer Keogh
- Matthew Russell as Ricky D'Angelo
- Mary Regency Boies as Regina
- Patsy Meck as Nancy
- Bonnie Aarons as Ricky D'Angelo's Mother
- Ted Barba as Doug Culpepper
- Madhu Narula as Dr. Patel's Wife
- Samantha Gelnaw as Jake's Fiancee
- Tiffany E. Green as Tanya
- Luisa Diaz as MILF