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- Natasha Lyonne as Vivian Abromowitz
- Alan Arkin as Murray Samuel Abromowitz
- Marisa Tomei as Rita Abromowitz
- Kevin Corrigan as Eliot Arenson
- David Krumholtz as Ben Abromowitz
- Eli Marienthal as Rickey Abromowitz
- Carl Reiner as Mickey Abromowitz
- Rita Moreno as Belle Abromowitz
- Mena Suvari as Rachel Hoffman
- Jessica Walter as Doris Zimmerman