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- Dwayne Johnson as John Matthews
- Barry Pepper as Agent Cooper
- Benjamin Bratt as Juan Carlos 'El Topo' Pintera
- Susan Sarandon as Joanne Keeghan
- Jon Bernthal as Daniel James
- Michael Kenneth Williams as Malik
- Melina Kanakaredes as Sylvie Collins
- Nadine Velazquez as Analisa Matthews
- Rafi Gavron as Jason Collins
- David Harbour as Jay Price
- JD Pardo as Benicio
- Kym Jackson as Agent Sims
- Ashlynn Ross as Amanda