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- Natasha Henstridge as Eve
- Michael Madsen as Press Lennox
- Marg Helgenberger as Dr. Laura Baker
- James Cromwell as Judson Ross
- Mykelti Williamson as Dennis Gamble
- Richard Belzer as U.S. President
- Justin Lazard as Patrick Ross
- Sarah Wynter as Melissa
- George Dzundza as Col. Carter Burgess Jr.
- Myriam Cyr as Anne Sampas
- Peter Boyle as Dr. Herman Cromwell
- Nancy La Scala as Marcy
- Raquel Gardner as Lucy
- Kim Adams as Darlene