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- Dustin Hoffman as Dr. Norman Goodman
- Sharon Stone as Dr. Elizabeth "Beth" Halperin
- Samuel L. Jackson as Dr. Harry Adams
- Liev Schreiber as Dr. Ted Fielding
- Peter Coyote as Capt. Harold C. Barnes
- Queen Latifah as Alice "Teeny" Fletcher
- Marga Gomez as Jane Edmunds
- Huey Lewis as Helicopter Pilot