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- Glenn Close as Agent Karen Moore
- Maggie Gyllenhaal as Linda Sykes
- Bruno Lastra as Sharif Bin Said
- Dean Winters as Agent Ned McGrath
- Ken Leung as Liu Tsung-Yuan
- Jim Gaffigan as Reverend Craig Peterson
- Caroline Kava as Alvira Sykes
- Austin Pendleton as James Perley
- Tom Guiry as Gerry Sykes
- Fred Koheler as Jimmy Briggs