|Principal Cast||Jared Padalecki, Jensen Ackles, Katie Cassidy, Lauren Cohan, Misha Collins, Mark Sheppard|
|No. of Seasons||10|
|No. of Episodes||205|
|Start Date||September 13, 2005|
- Dean Winchester
- Sam Winchester
- Bobby Singer
- Bela Talbot
- John Winchester
While Sam studies at Stanford, Dean hunts monsters for a living by himself. One day, Dean breaks into Sam's home and asks him to help find their father. After doing a job together, Sam returns to find his girlfriend, Jessica, killed in the same way like their mother did. Sam joins Dean in their quest to find their father and track down the demon who killed their mother and loved ones.
Knowing the name of the demon who killed both their parents, Sam and Dean track down Azazel and stop his plans which involves psychic children who had similar circumstances to Sam's.
After Sam learns that Dean has been resurrected as a demon due to the Mark of Cain, he and Castiel capture Dean in order to cure him. Despite their efforts, Dean did return to normal but has anger issues due to the Mark of Cain. Meanwhile, Castiel searches for Novak's daughter, Claire, with the help of the Winchester brothers. While Dean battles to control himself, Charlie discovers the Book of the Damned. Because of Dean's refusal of dark magic due to the uncertain consequences, Sam resorts to lying and keeping a secret from Dean. Sam involves Castiel, Charlie, and Rowena in decoding the Book of the Damned which had unintended consequences. Charlie was slain by the Steins family who was searching for the book. This causes Dean to wipe out the family in revenge.
Dean resorts to his last option, asking Death for help. However, Death cannot remove the Mark of Cain but can move him to a place far away from Earth. In return for his services, Death asks Dean to kill his brother because Sam will do anything to bring back Dean. In a critical moment of decision, Dean kills Death. At the same time, Rowena casts the spell which removes Dean's Mark of Cain. This causes the Darkness to escape.