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- Felicity Huffman as Sabrina "Bree" Osbourne
- Kevin Zegers as Toby Wilkins
- Graham Greene as Calvin Many Goats
- Fionnula Flanagan as Elizabeth Schupak
- Burt Young as Murray Schupak
- Carrie Preston as Sydney Schupak
- Elizabeth Pena as Margaret
- Danny Burstein as Dr. Spikowsky