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- Bruce Willis as James Cole
- Madeleine Stowe as Kathryn Railly
- Brad Pitt as Jeffrey Goines
- Christopher Plummer as Dr. Goines
- Jon Seda as Jose
- Christopher Meloni as Lt. Halperin
- David Morse as Dr. Peters
- Frank Gorshin as Dr. Fletcher
- Vernon Campbell as Tiny
- Lisa Gay Hamilton as Teddy