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- Katherine Heigl as Abigail "Abby" Richter
- Gerard Butler as Mike Chadway
- Eric Winter as Colin Anderson
- Nick Searcy as Stuart
- Cheryl Hines as Georgia Bordeney
- John Michael Higgins as Larry Williams
- Bree Turner as Joy Haim
- Kevin Connolly as Jim Ryan
- Bonnie Somerville as Elizabeth
- Yvette Nicole Brown as Dori Coleman
- Craig Ferguson as Himself