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- Jean-Claude Van Damme as Luc Deveraux
- Michael Jai White as S.E.T.H.
- Heidi Schanz as Erin Young
- Xander Berkeley as Doctor Dylan Cotner
- Justin Lazard as Captain Blackburn
- Kiana Tom as Maggie
- Daniel von Bargen as General Radford
- James R. Black as Sergeant Morrow
- Karis Paige Bryant as Hillary Deveraux
- Bill Goldberg as Romeo
- Lyle Kanouse as UniSol 2500