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- Jon Bon Jovi as Derek Bliss
- Cristian de la Fuente as Father Rodrigo
- Natasha Gregson Wagner as Zoey
- Arly Jover as Una
- Darius McCrary as Ray Collins
- Diego Luna as Sancho
- Anilu Pardo as Nurse Lupe
- Javier Grajeda as Brody
- Antonio Muniz as Jesse Brooks
- Muriel Fouilland as Miss Brazil