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- Tommy Lee Jones as Mike Roark
- Anne Heche as Dr. Amy Barnes
- Gaby Hoffmann as Kelly Roark
- Don Cheadle as Emmit Reese
- Jacqueline Kim as Dr. Jaye Calder
- Keith David as Ed Fox
- John Corbett as Norman Calder
- Michael Rispoli as Gator Harris
- John Carroll Lynch as Stan Olber
- Dayton Callie as Roger Lapher