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- Martin Lawrence as Roscoe Steven Jenkins
- Joy Bryant as Bianca Kittles
- James Earl Jones as Roscoe Steven "Papa" Jenkins, Sr.
- Margaret Avery as Mama Jenkins
- Mike Epps as Reggie Jenkins
- Mo'Nique as Betty Jenkins
- Cedric the Entertainer as Clyde Stubbs
- Nicole Ari Parker as Lucinda Allen
- Michael Clarke Duncan as Otis Jenkins
- Liz Mikel as Ruthie Jenkins
- Brooke Lyons as Amy
- Louis C.K. as Marty
- Niecy Nash as Cameo