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- Harrison Ford as Dr. Norman Spencer
- Michelle Pfeiffer as Claire Spencer
- Diana Scarwid as Jody
- Miranda Otto as Mary Feur
- James Remar as Warren Feur
- Katharine Towne as Caitlin Spencer
- Wendy Crewson as Elena
- Joe Morton as Dr. Drayton
- Amber Valletta as Madison Elizabeth Frank
- Ray Baker as Dr. Stan Powell